March 05, 2018
Safety Analysis of Leishmania Vaccine Used in a Randomized Canine Vaccine/Immunotherapy Trial
In Leishmania infantum–endemic countries, controlling infection within dogs, the domestic reservoir, is critical to public health. There is a need for safe vaccines that prevent canine progression with disease and transmission to others. Protective vaccination against Leishmania requires mounting a strong, inflammatory, Type 1 response. Three commercially available canine vaccines on the global veterinary market use saponin or inflammatory antigen components (Letifend) as a strong pro-inflammatory adjuvant. There is very little information detailing safety of saponin as an adjuvant in field trials. Safety analyses for the use of vaccine as an immunotherapeutic in asymptomatically infected animals are completely lacking. Leishmania infantum, the causative agent of canine leishmaniasis, is enzootic within U.S. hunting hounds. We assessed the safety of LeishTec® after use in dogs from two different clinical states: 1) without clinical signs and tested negative on polymerase chain reaction and serology or 2) without clinical signs and positive for at least one Leishmania diagnostic test. Vaccine safety was assessed after all three vaccinations to quantify the number and severity of adverse events. Vaccinated animals had an adverse event rate of 3.09%, whereas placebo animals had 0.68%. Receiving vaccine was correlated with the occurrence of mild, site-specific, reactions. Occurrence of severe adverse events was not associated with having received vaccine. Infected, asymptomatic animals did not have a higher rate of adverse events. Use of vaccination is, therefore, likely to be safe in infected, asymptomatic animals.
Read the full article in The American of Tropical Medicine and Hygiene.
More from CNAS
-
Will Europe Send Combat Forces to Ukraine?
Commentary
Any idea that Europe could deter Russia from breaking a cease-fire and renewing its attack with the presence of a light peacekeeping force is fantasy....
By Franz-Stefan Gady
-
There Is Still Much To Know About Drone Sightings on the East Coast
Podcast
NPR's Steve Inskeep talks to Stacie Pettyjohn of the Center for a New American Security, about why the federal government hasn't provided more details about drones spotted ove...
By Stacie Pettyjohn
-
Defense Expert Weighs In on Mysterious Drone Sightings
Video
Stacie Pettyjohn, director of the defense program at the think tank Center for a New American Security, discusses the drone sightings, which some officials are calling "a slig...
By Stacie Pettyjohn
-
How Trump Will Change the World
Commentary
Trump has won the chance to determine U.S. national security policy and will wield the impressive power embodied in the men and women now waiting to work for him....
By Peter Feaver
